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Computational protein design for hybrid nanopore sensors
Leuven | Just now
Harness protein design to build nanotechnology
This internship
project addresses a key issue of nanopore technology: the integration of the
biopore with electronic devices. By designing new proteins that better
interface solid-state nanopore technologies, we aim to enable the assembly of a
dense array of individually readable nanometer-scaled protein nanopores on a
sensor chip. Such a “hybrid nanopore” concept would open the door to next
generation DNA and protein sequencing approaches, as well as the development of
novel wearable devices and point-of-care technologies for the real-time
identification of molecules and biomarkers. In this Master thesis computational
protein design will be leveraged to develop versatile hybrid nanopores. To find
the best possible fit to solid-state pores, we will use de novo design and
high-throughput experiments combined with cutting-edge semiconductor processing
techniques. The Master thesis involves both wet lab and computational work with
a balance that can be adapted to the candidate expertise/interests. The project proposed is a collaboration between VUB and IMEC.
Type of internship: PhD internship, Master internship
Duration: 5-6 months
Required educational background: Bioscience Engineering, Chemistry/Chemical Engineering, Nanoscience & Nanotechnology, Physics, Electrotechnics/Electrical Engineering, Materials Engineering
University promotor: Pol Van Dorpe (KU Leuven)
Supervising scientist(s): For further information or for application, please contact Jose Morales Hellin (Jose.MoralesHellin@imec.be) and Koen Martens (Koen.Martens@imec.be)
The reference code for this position is 2026-INT-073. Mention this reference code in your application.
Applications should include the following information:
- resume
- motivation
- current study
Incomplete applications will not be considered.