Antwerpen | More than two weeks ago
Biochemical reactions are fundamental to numerous biological processes and applications, from metabolic pathways to drug interactions and gene regulation. However, accurately modeling these reactions remains a challenge due to their complexity, nonlinearity, and stochastic nature. This research project aims to create a baseline hybrid modeling framework that integrates traditional reaction kinetics with advanced AI and data-driven approaches to provide a flexible and robust tool for understanding and predicting biochemical dynamics.
The proposed framework will combine classical kinetic models with machine learning techniques, allowing for the incorporation of diverse data sources, such as experimental measurements and simulations. By developing a set of hybrid base models, we will establish a foundation that captures the core principles of reaction kinetics while remaining adaptable to different biochemical contexts. These base models will be designed to be extensible and modular, providing a flexible platform that can be tailored to various specific applications in biomanufacturing.
The development of this hybrid approach will provide a versatile tool for researchers and practitioners in fields like biopharmaceutical development and systems biology. It will enable them to model, predict, and manipulate biochemical reactions with greater precision and flexibility. Ultimately, this research aims to create a general-purpose modeling platform that can accelerate innovation across the life sciences by bridging traditional reaction kinetics with cutting-edge AI techniques.
Required background: Master’s degree in Computer Science, Informatics, Physics, (biochemical) Engineering or Electronics, with knowledge about artificial intelligence and machine learning
Type of work: 70% modeling/simulation, 20% experimental, 10% literature
Supervisor: Siegfried Mercelis
Co-supervisor: Catherine Middag
Daily advisor: Furkan Elmaz
The reference code for this position is 2025-119. Mention this reference code on your application form.