DNA-mediated electrochemistry
Leuven | Just now
Harnessing biological machinery (e.g., enzymes) on solid-state platforms is a “holy grail” in nanotechnology, with applications ranging from DNA synthesis to high-precision diagnostics. However, a fundamental mismatch exists: biological molecules are soft, ionic, and structurally complex, while electronics are rigid and electron-based. Creating a reproducible, electrically active junction between a protein and a metal electrode remains a significant scientific bottleneck.
his project explores DNA nanotechnology - specifically DNA origami and modified DNA strands - as the ultimate interface material. DNA offers programmable precision for positioning enzymes and unique charge-transport properties that can be tuned to facilitate direct electrical communication between the electrode and the biological machine.
You will join a multidisciplinary team investigating how DNA nanostructures can serve as a conductive bridge to control enzyme function. You will contribute to advancing our understanding of how electrical potential can actively control enzymatic activity via DNA-mediated charge transport, moving beyond mere observation.
Scope of work
- Microfabrication: Process micro-electrode arrays (MEAs) in the cleanroom using photolithography and thin-film deposition techniques.
- Surface engineering: Optimize site-selective functionalization protocols (e.g., silanization, electrografting, click-chemistry) to anchor DNA to metal electrodes.
- Electrochemical characterization: Deeply investigate the interface using cyclic voltammetry, electrochemical impedance spectroscopy, and chronocoulometry.
- Data analysis & modeling: Analyze complex electrochemical datasets using scripting and correlate findings with theoretical models of biomolecular charge transport.
- Literature review: Develop an in-depth, targeted understanding of DNA-mediated charge transfer based on existing literature.
This internship provides practical experience at imec Leuven (Belgium), a world-renowned microelectronics research institute, where innovative scientific research is applied to address real-world challenges. Interns will have the opportunity to collaborate with imec professionals and access advanced laboratory facilities within an international setting.
- You should have a solid theoretical foundation in electrochemistry and surface science.
- You have a strong interest in experimental work within both cleanroom and wet laboratory environments.
- You should have a high ambition to learn and a commitment to developing new skills.
Type of internship: Master internship, PhD internship
Duration: >4 months FTE
Required educational background: Nanoscience & Nanotechnology, Bioscience Engineering, Chemistry/Chemical Engineering
University promotor: Philippe Vereecken (KU Leuven)
Supervising scientist(s): For further information or for application, please contact Kherim Willems (Kherim.Willems@imec.be)
The reference code for this position is 2026-INT-004. Mention this reference code in your application.
Only for self-supporting students.
Applications should include the following information:
- resume
- motivation
- current study
Incomplete applications will not be considered.